Biological and Medical Applications of Materials and Interfaces
- Shujun Cao
Shujun Cao
Research Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology, Innovation Center, Nanjing Tech University, Nanjing 211816, China
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- Peihong Ji
Peihong Ji
Research Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology, Innovation Center, Nanjing Tech University, Nanjing 211816, China
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- Rongjian Ding
Rongjian Ding
Research Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology, Innovation Center, Nanjing Tech University, Nanjing 211816, China
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- Hao Xia
Hao Xia
Research Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology, Innovation Center, Nanjing Tech University, Nanjing 211816, China
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- Hongli Mao*
Hongli Mao
Research Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology, Innovation Center, Nanjing Tech University, Nanjing 211816, China
*Email: [emailprotected]
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Zhongwei Gu
Research Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology, Innovation Center, Nanjing Tech University, Nanjing 211816, China
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
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https://pubs.acs.org/doi/10.1021/acsami.5c04195
Published April 28, 2025
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Deep trauma often leads to acute bleeding and infections, which are major causes of death. It is worth exploring the preparation of hemostatic materials and improving their hemostatic and antibacterial properties applied to deep trauma by green and efficient methods. In this study, porous chitosan/zinc oxide/alkylated chitosan (CS/ZnO/ACS) sponges were prepared by a freezing phase separation method. ACS induced the formation of stable foam, increasing the pore formation during the freezing phase separation process. The porous structure enabled the sponge to rapidly absorb blood and expand to close the wound. The in situ synthesis of ZnO within the sponge enhances its antibacterial properties. In the antibacterial test against S. aureus and E. coli, the CS/ZnO/ACS sponges can effectively inhibit bacterial growth. Besides, compared with CS sponges, the introduction of ACS increases the adhesion of the CS/ZnO/ACS sponges to blood cells and promotes coagulation. In addition, the CS/ZnO/ACS sponges were prepared by physical phase separation, which endows it with increased solubility under acidic conditions and can be quickly removed after hemostasis. Therefore, the CS/ZnO/ACS expandable sponges offer promising clinical applications for the treatment of deep trauma.
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© 2025 American Chemical Society
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- Absorption
- Anatomy
- Antibacterial activity
- Oxides
- Wound healing
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
Click to copy citationCitation copied!
Published April 28, 2025
Publication History
Received
Accepted
Revised
Published
online
© 2025 American Chemical Society
Request reuse permissions
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